PT Article
AU Wang, Z
   Liu, C
   Pei, W
   Zhang, T
   Zhang, J
   Fan, W
   Wei, X
   Tu, J
   Wang, X
   Yang, N
AF Wang, Zeyi
   Liu, Cunzhi
   Pei, Wei
   Zhang, Tianzhen
   Zhang, Jing
   Fan, Wenwen
   Wei, Xiaoya
   Tu, Jianfeng
   Wang, Xu
   Yang, Nana
TI Investigating the efficacy of electroacupuncture for postoperative ileus in patients with colorectal cancer: study protocol for a multicentre clinical trial with neuroimaging assessment
SO BMJ Open
LA English
DT Article
DE Acupuncture; Colorectal surgery; COMPLEMENTARY MEDICINE; Functional bowel disorders; Functional Magnetic Resonance Imaging; Motility disorders
ID adult; adverse event; china; colorectal tumor; diagnostic imaging; electroacupuncture; etiology; female; human; ileus; laparoscopy; male; middle aged; multicenter study (topic); neuroimaging; nuclear magnetic resonance imaging; postoperative complication; procedures; randomized controlled trial (topic); surgery; therapy; treatment outcome; adult; colorectal neoplasms; electroacupuncture; female; humans; ileus; laparoscopy; magnetic resonance imaging; male; middle aged; multicenter studies as topic; neuroimaging; postoperative complications; randomized controlled trials as topic; treatment outcome
AB INTRODUCTION: Postoperative ileus (POI) is a prevalent complication following abdominal surgeries, significantly compromising patients' quality of life and imposing a socioeconomic burden. Electroacupuncture (EA), a widely used therapeutic approach in China, has shown promise as an effective intervention for POI. However, the neural mechanism underlying its therapeutic effects remains unclear. Thus, this study aims to evaluate the efficacy of EA treatment for POI and investigate its central mechanism by functional MRI (fMRI). METHODS AND ANALYSIS: This randomised controlled clinical trial will be conducted across three hospitals in China. A total of 50 eligible patients with colorectal cancer scheduled for elective laparoscopic surgery will be randomly assigned to either the EA or sham electroacupuncture (SA) group in a 1:1 ratio. All patients will undergo 5 sessions of 30 min EA or SA over 5 consecutive days post-surgery (once daily). Resting-state fMRI (rs-fMRI) scans will be performed at baseline and the end of treatment to examine brain functional changes related to EA treatment. The primary outcome is the time to first defecation. Secondary outcomes include the time to first flatus, ambulation, tolerability of semiliquid and solid food; length of postoperative hospital stay; severity of postoperative pain, abdominal distension and nausea; frequency of postoperative nausea and vomiting episodes; rate of readmission. Postoperative complications will be monitored and documented throughout the trial duration. Credibility and expectancy evaluation, along with blinding assessment, will be conducted after the first treatment session. Pearson/Spearman correlation analysis will be performed to determine the relationship between clinical variables and rs-fMRI metrics. ETHICS AND DISSEMINATION: This protocol has been approved by the ethics committees of Beijing University of Chinese Medicine (number 2024BZYLL0113), Cancer Hospital Chinese Academy of Medical Sciences (number 24/323-4603), Beijing Friendship Hospital Affiliated to Capital Medical University (number 2024-P2-081-01) and Beijing Chaoyang Huanxing Cancer Hospital (number 2024-011-02). Participants will sign the paper-based informed consent form before enrolment. The results will be disseminated through peer-reviewed publications. TRIAL REGISTRATION NUMBER: ITMCTR2024000504. © Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group.
C1 Beijing University of Chinese Medicine, Wang, Zeyi, School of Acupuncture-Moxibustion and Tuina, Beijing, China
   Beijing University of Chinese Medicine, Liu, Cunzhi, School of Acupuncture-Moxibustion and Tuina, Beijing, China
   Pei, Wei, Department of Colorectal Surgery, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
   Capital Medical University, Zhang, Tianzhen, Department of General Surgery, Beijing, China, Beijing, China, Beijing, China
   Huanxing Cancer Hospital, Zhang, Jing, Department of Surgery, Beijing, Beijing, China
   Fan, Wenwen, Department of Radiology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
   Beijing University of Chinese Medicine, Wei, Xiaoya, School of Acupuncture-Moxibustion and Tuina, Beijing, China
   Beijing University of Chinese Medicine, Tu, Jianfeng, School of Acupuncture-Moxibustion and Tuina, Beijing, China
   Beijing University of Chinese Medicine, null, null, School of Acupuncture-Moxibustion and Tuina, Beijing, China
   Beijing University of Chinese Medicine, Wang, Xu, School of Life Sciences, Beijing, China
   Beijing University of Chinese Medicine, Yang, Nana, School of Acupuncture-Moxibustion and Tuina, Beijing, China
NR 0
TC 0
SN 20446055
EI 
J9 BMJ OPEN
JI BMJ Open
PD JUN 15
PY 2025
VL 15
IS 12
BP e108722
EP 
DI 10.1136/bmjopen-2025-108722
PG 0
UT Scopus:10.1136/bmjopen-2025-108722
ER

PT Article
AU Chen, C
   He, L
AF Chen, Caiyi
   He, Lingling
TI Effects of different intensities of electroacupuncture and manual acupuncture at "Shangjuxu" (ST37) on acute inflammatory visceral pain and their relationship with α7nAChR/PI3K/AKT signaling pathway
SO Zhen Ci Yan Jiu
LA Chinese
DT Article
DE Acute inflammatory visceral pain; Electroacupuncture; Manual acupuncture; Shangjuxu(ST37); α7nAChR/PI3K/AKT signaling pathway
ID bungarotoxin receptor; phosphatidylinositol 3 kinase; protein kinase b; acupuncture; acupuncture point; animal; electroacupuncture; genetics; human; immunology; male; metabolism; rat; signal transduction; sprague dawley rat; therapy; visceral pain; acupuncture points; acupuncture therapy; alpha7 nicotinic acetylcholine receptor; animals; electroacupuncture; humans; male; phosphatidylinositol 3-kinases; proto-oncogene proteins c-akt; rats; rats, sprague-dawley; signal transduction; visceral pain
AB 目的: 对比不同刺激强度电针与手针治疗急性炎性内脏痛的效应差异;观察手针与（等效）电针通过α7烟碱乙酰胆碱受体（α7nAChR）/磷脂酰肌醇3-激酶（PI3K）/蛋白激酶B（AKT）通路治疗急性炎性内脏痛的机制差异。方法: 将SD大鼠随机分为正常组、模型组、电针1 mA组、电针2 mA组、电针3 mA组、电针4 mA组、电针6 mA组、手针组，每组12只。用2%乙酸灌肠制作急性炎性内脏痛大鼠模型。电针组分别采用对应电流强度电针（2 Hz）刺激“上巨虚”，手针组针刺“上巨虚”，刺激频率为2次/s，均持续干预2 min。HE染色法检测结肠黏膜组织病理形态变化，腹部撤回反射（AWR）评分和腹外斜肌放电幅值测定大鼠内脏痛，对比手针与不同强度电针的效应差异。选取与手针组等效的电针2 mA组，以及应用甲基乌头碱（MLA，α7nAChR阻断剂，4 mg/kg）的手针+MLA组和电针2 mA+MLA组，对比加用阻断剂后电针和手针镇痛效应的变化，ELISA法检测大鼠血清肿瘤坏死因子α（TNF-α）、白细胞介素-1β（IL-1β）含量，Western blot法检测大鼠结肠α7nAChR、PI3K、AKT蛋白表达。结果: 与正常组比较，模型组大鼠AWR评分和腹外斜肌放电幅值升高（P<0.05）;与模型组比较，1、2 mA电针组及与电针各组相同频率相同刺激时间的手针组大鼠AWR评分和腹外斜肌放电幅值降低（P<0.05），结肠黏膜炎性浸润及形态异常均有所改善。与正常组比较，模型组大鼠血清TNF-α、IL-1β含量，结肠PI3K、AKT蛋白表达升高（P<0.05），结肠α7nAChR蛋白表达降低（P<0.05）;与模型组比较，与2 mA等效的手针组和电针2 mA组大鼠血清TNF-α、IL-1β含量，结肠PI3K、AKT蛋白的表达降低（P<0.05），结肠α7nAChR蛋白表达升高（P<0.05），且手针和2 mA电针降低AWR评分，血清TNF-α、IL-1β含量，结肠PI3K、AKT蛋白表达及升高结肠α7nAChR蛋白表达的效应均能被α7nAChR的阻断剂MLA抑制（P<0.05）。结论: 1 mA、2 mA强度电针及与其相同频率（2 Hz）相同刺激时间（2 min）的手针具有类似的急性炎性内脏痛镇痛效应，此效应优于较高强度（3、4、6 mA）的电针;手针与电针“上巨虚”缓解急性炎性内脏痛的作用机制，可能与α7nAChR/PI3K/AKT信号通路密切相关。.; OBJECTIVES: To compare the effects of electroacupuncture (EA) and manual acupuncture (MA) at different stimulation intensities on acute inflammatory visceral pain, and to analyze their mechanisms underlying relief of inflammatory visceral pain mediated by α7 nicotinic acetylcholine receptor (α7nAChR)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signaling pathway. METHODS: Male SD rats were randomly divided into normal control, visceral pain model, EA 1 mA, EA 2 mA, EA 3 mA, EA 4 mA, EA 6 mA, and MA groups (with the same frequency as EA, 2 times/s, for 2 min), with 12 rats in each group. The acute inflammatory visceral pain model was established by intracolonic instillation of 2% acetic acid. EA (2 Hz, 1, 2, 3, 4, 6 mA) or MA (120 twirlings/min, with the needle rotated at a magnitude of about 90°-180°) was applied to the right Shangjuxu (ST37) for 2 min. The abdominal withdrawal reflex (AWR) score and external oblique muscle electromyogram amplitude were used to assess the visceral pain reaction. Histopathological changes of the colonic mucosal tissue were detected by H.E. staining. For observing the involvement of colonic α7nAChR in visceral pain relief of both EA and MA, intraperitoneal injection of methylaconitine (MLA, α7nAChR blocker, 4 mg/kg) was given to rats of MA+MLA and EA 2 mA+MLA groups (with 6 rats in each group) before each intervention. The contents of serum tumor necrosis factor-α(TNF-ɑ) and interleukin-1β(IL-1β) were detected by enzyme-linked immunosorbent assay (ELISA). The expression levels of α7nAChR, PI3K and AKT in the colon tissue were detected by Western blot. RESULTS: In comparison with the normal control group, both the AWR scores and the amplitude of EMG at colorectal dilation (CRD) pressure of 20, 40, 60 and 80 mmHg were significantly increased in the model group (P<0.05). Compared with the model group, both the AWR scores and the amplitude of EMG at CRD pressure of 20, 40, 60 and 80 mmHg were significantly decreased in the EA 1 mA, EA 2 mA and MA groups (P<0.05), rather than in the EA 3 mA, EA 4 mA and EA 6 mA groups, suggesting that the higher stimulation intensity of EA had no analgesic effect. H.E. staining showed slightly hyperemic and edematous injury of the colonic mucosa tissue, with obvious inflammatory infiltration and abnormal morphological changes in the model group, which was obviously milder in the injury in the MA and EA 1 mA, EA 2 mA groups, rather than in the EA 3 mA, 4 mA and 6 mA groups. In comparison with the normal control group, the contents of serum TNF-ɑ and IL-1β, and expression levels of PI3K and AKT proteins in colon were significantly increased (P<0.05), and the expression of α7nAChR protein was remarkably down-regulated (P<0.05) in the model group. Compared with the model group, the contents of serum TNF-ɑ and IL-1β, and the expression levels of PI3K and AKT proteins were strikingly down-regulated (P<0.05), and the expression of α7nAChR was considerably up-regulated (P<0.05) in both EA 2 mA and MA groups. Moreover, the effects of reducing the corresponding AWR scores at various CRD pressure levels, serum TNF-α and IL-1β contents, and the protein expressions of PI3K and AKT in colon, as well as increasing the protein expression of α7nAChR in colon in rats of MA and EA 2 mA groups can be inhibited by MLA (P<0.05), a blocker of α7nAChR. CONCLUSIONS: Both MA and 2 mA EA (not 3, 4, 6 mA EA) stimulation of ST37 have a similar analgesic effect in acute inflammatory visceral pain rats, which may be related to their function in suppressing the activities of α7nAChR/PI3K/AKT signaling pathway.
C1 Fujian Normal University, Chen, Caiyi, Acupuncture and moxibustion Massage College, Fuzhou, Fujian, China
   Fujian Normal University, null, null, Acupuncture and moxibustion Massage College, Fuzhou, Fujian, China
   Fujian Normal University, null, null, Acupuncture and moxibustion Massage College, Fuzhou, Fujian, China
   Fujian Normal University, He, Lingling, Acupuncture and moxibustion Massage College, Fuzhou, Fujian, China
   Fujian Normal University, null, null, College of Education, Fuzhou, Fujian, China
NR 0
TC 0
SN 10000607
EI 
J9 ZHEN CI YAN JIU
JI Zhen Ci Yan Jiu
PD JUN 15
PY 2025
VL 50
IS 12
BP 1365
EP 1375
DI 10.13702/j.1000-0607.20250327
PG 11
UT Scopus:10.13702/j.1000-0607.20250327
ER

PT Article
AU Houran, L
   Pucka, AQ
   Jiang, MC
   Liu, Z
   O'brien, AR
   Harte, SE
   Harris, RE
   Pakbaz, Z
   Wang, Y
AF Houran, Lina
   Pucka, Andrew q
   Jiang, Mio cate
   Liu, Ziyue
   O'brien, Andrew rw
   Harte, Steve e
   Harris, Richard edmund
   Pakbaz, Zahra
   Wang, Ying
TI Acupressure alleviates pain and clinical symptoms in patients with sickle cell disease
SO Blood Advances
LA English
DT Article
DE 
ID hydroxyurea; placebo; acupressure; adolescent; adult; anxiety; article; body mass; breast cancer; cancer survivor; clinical article; controlled study; depression; dysmenorrhea; fatigue; female; follow up; human; low back pain; male; opioid induced hyperalgesia; pain severity; quality of life; randomized controlled trial; sickle cell anemia; sickle cell crisis; sleep disorder
AB [No abstract available]
C1 Indiana University School of Medicine, Houran, Lina, Department of Anesthesiology, Indianapolis, IN, United States
   Indiana University School of Medicine, Department of Anesthesiology, Indianapolis, IN, United States
   Jiang, Mio Cate, UCI School of Medicine, Irvine, CA, United States
   Indiana University School of Medicine, Liu, Ziyue, Department of Biostatistics and Health Data Science, Indianapolis, IN, United States
   Indiana University School of Medicine, O'Brien, Andrew Rw, Division of Hematology and Oncology, Indianapolis, IN, United States
   University of Michigan Medical School, Department of Anesthesiology, Ann Arbor, MI, United States
   University of Michigan Medical School, Harris, Richard Edmund, Department of Anesthesiology, Ann Arbor, MI, United States, Department of Anesthesiology and Perioperative Care, UCI School of Medicine, Irvine, CA, United States, UCI School of Medicine, Irvine, CA, United States
   Pakbaz, Zahra, UCI School of Medicine, Irvine, CA, United States
   Indiana University School of Medicine, Wang, Ying, Department of Anesthesiology, Indianapolis, IN, United States, Division of Hematology and Oncology, Indianapolis, IN, United States
CR Song, Hyun-jin, Effect of self-acupressure for symptom management: A systematic review, Complementary Therapies in Medicine, 23, 1, pp. 68-78, (2015), 2015, Song @ Hyun-jin, VEffect of self-acupressure for symptom management: A systematic review, P68-78
   He, Yihan, Clinical Evidence for Association of Acupuncture and Acupressure with Improved Cancer Pain: A Systematic Review and Meta-Analysis, JAMA Oncology, 6, 2, pp. 271-278, (2020), 2020, He @ Yihan, VClinical Evidence for Association of Acupuncture and Acupressure with Improved Cancer Pain: A Systematic Review and Meta-Analysis, P271-278
   Karakuş Selçuk, Aslı, Effect of acupressure on primary dysmenorrhea: Review of experimental studies, JAMS Journal of Acupuncture and Meridian Studies, 14, 2, pp. 33-49, (2021), 2021, Karakuş Selçuk @ Aslı, VEffect of acupressure on primary dysmenorrhea: Review of experimental studies, P33-49
   Alimoardi, Zainab, Effects of ear and body acupressure on labor pain and duration of labor active phase: A randomized controlled trial, Complementary Therapies in Medicine, 51, (2020), 2020, Alimoardi @ Zainab, VEffects of ear and body acupressure on labor pain and duration of labor active phase: A randomized controlled trial, P51
   Murphy, Susan L, 2019, Self-Administered Acupressure for Chronic Low Back Pain: A Randomized Controlled Pilot Trial @ Pain Medicine (United States), V20, P2588-2597
   Zick, Suzanna M, 2016, Investigation of 2 types of self-Administered acupressure for persistent cancer-related fatigue in breast cancer survivors a randomized clinical trial @ JAMA Oncology, V2, P1470-1476
   Osunkwo, Ifeyinwa, Optimizing the management of chronic pain in sickle cell disease, Hematology (United States), 20, 1, pp. 562-569, (2020), 2020, Osunkwo @ Ifeyinwa, VOptimizing the management of chronic pain in sickle cell disease, P562-569
   Smith, Wally R, 2008, Daily assessment of pain in adults with sickle cell disease @ Annals of Internal Medicine, V148, P94-101
   Zaidi, Ahmar Urooj, A systematic literature review of frequency of vaso-occlusive crises in sickle cell disease, Orphanet Journal of Rare Diseases, 16, 1, (2021), 2021, Zaidi @ Ahmar Urooj, VA systematic literature review of frequency of vaso-occlusive crises in sickle cell disease, P1
NR 9
TC 0
SN 24739529
EI 
J9 BLOOD ADV
JI Blood Adv.
PD JUN 15
PY 2025
VL 9
IS 23
BP 6126
EP 6129
DI 10.1182/bloodadvances.2025016995
PG 4
UT Scopus:10.1182/bloodadvances.2025016995
ER

PT Article
AU Li, Y
   Xu, R
   Chen, M
   Zheng, K
   Nie, H
   Yin, C
   Liu, B
   Tai, Y
   Du, J
   Wang, J
   Fang, J
   Liu, B
AF Li, Yuanyuan
   Xu, Ruoyao
   Chen, Muyan
   Zheng, Kaige
   Nie, Huimin
   Yin, Chengyu
   Liu, Boyu
   Tai, Yan
   Du, Junying
   Wang, Jie
   Fang, Jianqiao
   Liu, Boyi
TI Electroacupuncture alleviates paclitaxel-induced peripheral neuropathy by reducing CCL2-mediated macrophage infiltration in sensory ganglia and sciatic nerve
SO Chinese Medicine (United Kingdom)
LA English
DT Article
DE Acupuncture; Chemotherapy; Macrophages; Neuropathy; Paclitaxel; Pain
ID monocyte chemotactic protein 1; paclitaxel; 4t1 cell line; animal experiment; animal model; animal tissue; antineoplastic activity; article; bagg albino mouse; c57bl 6 mouse; clinical effectiveness; cold hyperalgesia; controlled study; dose response; drug effect; drug efficacy; drug mechanism; electroacupuncture; female; flow cytometry; immunohistochemistry; in vivo study; intra epidermal nerve fiber; kunlun acupoint; m1 macrophage; m2 macrophage; macrophage; male; mechanical hyperalgesia; mouse; nerve fiber; nonhuman; peripheral neuropathy; sciatic nerve; sensory ganglion; sensory nerve cell; spinal ganglion; treatment outcome; tumor volume; tumor xenograft; zusanli acupoint
AB Background: Paclitaxel-induced peripheral neuropathy (PIPN) is prevalent among patients receiving paclitaxel chemotherapy, which results in sensory abnormality as well as neuropathic pain. Conventional medications lack effectiveness on PIPN. Clinical trials identified beneficial effects of acupuncture on PIPN among patients receiving chemotherapy. Here we explored the mechanisms underlying how acupuncture might alleviate PIPN. Methods: A mouse model of PIPN was established by repeated paclitaxel application. Electroacupuncture (EA) was applied at ST36 and BL60 acupoints of model mice. Immunostaining, flow cytometry, behavioral assay, in vivo imaging were utilized for effects determination and mechanism exploration. Results: EA ameliorated mechanical and cold pain hypersensitivities, reduced sensory neuron damage and improved loss in intra-epidermal nerve fibers (IENFs) in model mice. Macrophages infiltration were detected in DRG and sciatic nerve of model mice, which was reduced by EA. EA affected M1-like pro-inflammatory macrophage infiltration in DRG, whereas it did not affect M2-like macrophages. DRG neurons released chemoattractant CCL2 that recruited macrophages via CCR2 to DRG. EA reduced CCL2 overproduction by DRG neurons and reduced macrophage infiltration. Blocking CCR2 mimicked EA’s anti-allodynic effect, whereas exogenously applying recombinant CCL2 reversed the ameliorative effect of EA on macrophage infiltration and abolished EA’s anti-allodynia on model mice. EA ameliorated other signs of PIPN, including sensory neuron damage, sciatic nerve morphology impairment and IENFs loss. In mice inoculated with breast cancer cells, EA didn’t affect paclitaxel-induced antitumor effect. Conclusions: These findings suggest EA alleviates PIPN by reducing CCL2/CCR2 mediated-pro-inflammatory macrophage infiltration into sensory ganglia as well as the sciatic nerve. Our study supports EA could be used as a potential non-pharmacological therapy for PIPN. © The Author(s) 2025.
C1 Zhejiang Chinese Medical University, Li, Yuanyuan, Department of Neurobiology and Acupuncture Research, Hangzhou, Zhejiang, China
   Zhejiang Chinese Medical University, Xu, Ruoyao, Department of Neurobiology and Acupuncture Research, Hangzhou, Zhejiang, China
   Zhejiang Chinese Medical University, Chen, Muyan, Department of Neurobiology and Acupuncture Research, Hangzhou, Zhejiang, China
   Zhejiang Chinese Medical University, Zheng, Kaige, Department of Neurobiology and Acupuncture Research, Hangzhou, Zhejiang, China
   Zhejiang Chinese Medical University, Nie, Huimin, Department of Neurobiology and Acupuncture Research, Hangzhou, Zhejiang, China
   Zhejiang Chinese Medical University, Yin, Chengyu, Department of Neurobiology and Acupuncture Research, Hangzhou, Zhejiang, China
   Zhejiang Chinese Medical University, Liu, Boyu, Department of Neurobiology and Acupuncture Research, Hangzhou, Zhejiang, China
   Zhejiang Chinese Medical University, Tai, Yan, Academy of Chinese Medical Sciences, Hangzhou, Zhejiang, China
   Zhejiang Chinese Medical University, Du, Junying, Department of Neurobiology and Acupuncture Research, Hangzhou, Zhejiang, China
   The Second Affiliated Hospital Zhejiang University School of Medicine, Wang, Jie, Department of Rehabilitation in Traditional Chinese Medicine, Hangzhou, Zhejiang, China
   Zhejiang Chinese Medical University, Fang, Jianqiao, Department of Neurobiology and Acupuncture Research, Hangzhou, Zhejiang, China
   Zhejiang Chinese Medical University, Liu, Boyi, Department of Neurobiology and Acupuncture Research, Hangzhou, Zhejiang, China
CR Mody, Mayur D, 2016, The evolving and future role of taxanes in squamous cell carcinomas of the head and neck a review @ JAMA Otolaryngology - Head and Neck Surgery, V142, P898-905
   Forsyth, Peter A.J, 1997, Prospective study of paclitaxel-induced peripheral neuropathy with quantitative sensory testing @ Journal of Neuro-Oncology, V35, P47-53
   Starobova, Hana, Pathophysiology of chemotherapy-induced peripheral neuropathy, Frontiers in Molecular Neuroscience, 10, (2017), 2017, Starobova @ Hana, VPathophysiology of chemotherapy-induced peripheral neuropathy, P10
   Brewer, Jamie Renee, Chemotherapy-induced peripheral neuropathy: Current status and progress, Gynecologic Oncology, 140, 1, pp. 176-183, (2016), 2016, Brewer @ Jamie Renee, VChemotherapy-induced peripheral neuropathy: Current status and progress, P176-183
   Flatters, Sarah J.L, 2017, Clinical and preclinical perspectives on Chemotherapy-Induced Peripheral Neuropathy (CIPN): A narrative review @ British Journal of Anaesthesia, V119, P737-749
   Loprinzi, Charles L, 2020, Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: ASCO guideline update @ Journal of Clinical Oncology, V38, P3325-3348
   Sisignano, Marco, Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain, Nature Reviews Neurology, 10, 12, pp. 694-707, (2014), 2014, Sisignano @ Marco, VMechanism-based treatment for chemotherapy-induced peripheral neuropathic pain, P694-707
   Jordan, Berit, Systemic anticancer therapy-induced peripheral and central neurotoxicity: ESMO–EONS–EANO Clinical Practice Guidelines for diagnosis, prevention, treatment and follow-up, Annals of Oncology, 31, 10, pp. 1306-1319, (2020), 2020, Jordan @ Berit, VSystemic anticancer therapy-induced peripheral and central neurotoxicity: ESMO–EONS–EANO Clinical Practice Guidelines for diagnosis, P1306-1319
   Chen, Ouyang, Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons, Current Opinion in Neurobiology, 62, pp. 17-25, (2020), 2020, Chen @ Ouyang, VRegulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons, P17-25
   Ji, R. R, 2016, Pain regulation by non-neuronal cells and inflammation @ Science, V354, P572-577
NR 10
TC 5
SN 19910150
EI 
J9 CHIN MED
JI Chin. Med
PD JUN 15
PY 2025
VL 20
IS 1
BP 
EP 
DI 10.1186/s13020-024-01023-8
PG 0
UT Scopus:10.1186/s13020-024-01023-8
ER

PT Article
AU Zhu, R
   Li, X
   Yan, Z
   Chen, C
   Zhai, W
   Zhang, H
   Ma, WJ
   Wang, F
   Liu, M
   Du, G
AF Zhu, Ruixin
   Li, Xing
   Yan, Zhaobo
   Chen, Cheng
   Zhai, Wei
   Zhang, Hengcai
   Ma, Wen juan
   Wang, Fukun
   Liu, Mi
   Du, Geshu
TI Efficacy and safety of acupuncture with moxibustion for knee osteoarthritis: a meta-analysis of randomized controlled trials
SO Systematic Reviews
LA English
DT Article
DE Acupuncture; Adverse events; Knee osteoarthritis; Meta-analysis; Moxibustion; Treatment
ID acupuncture; adverse event; article; drug efficacy; drug safety; follow up; human; knee osteoarthritis; meta analysis; moxibustion; outcome assessment; randomized controlled trial (topic); rigidity; sensitivity analysis; systematic review; treatment outcome; visual analog scale; multimodality cancer therapy; pain measurement; procedures; therapy; acupuncture therapy; combined modality therapy; humans; moxibustion; osteoarthritis, knee; pain measurement; randomized controlled trials as topic; treatment outcome
AB Background: Osteoarthritis (OA) is prevalent, yet its management remains challenging. This meta-analysis aims to evaluate the efficacy of acupuncture combined with moxibustion versus other standard treatments in patients with knee osteoarthritis (KOA) based on randomized controlled trials (RCTs). Methods: Searches were conducted in Ovid MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to retrieve relevant RCTs. Data on baseline characteristics, treatment efficacy, and adverse events were extracted. The analysis utilized pooled weighted mean differences (WMD) and risk ratios (RR) with 95% confidence intervals (CIs) to assess the superior treatment modality. Results: A total of 18 RCTs were included. Acupuncture combined with moxibustion demonstrated significant improvement in the visual analog scale (VAS) for pain and the long-term (> 60 weeks) Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores for pain, stiffness, and physical function compared to other treatments. In contrast, short- (< 4 weeks) and mid-term (6–60 weeks) WOMAC outcomes for pain, stiffness, and physical function indicated varied results. The overall efficacy rate also favored the combined therapy significantly in the short- and mid-term evaluations. Notably, this therapy was associated with fewer adverse events. Conclusion: The meta-analysis reveals that acupuncture combined with moxibustion is notably more effective and safer than other treatment modalities for KOA, particularly during mid- and long-term follow-up periods. © The Author(s) 2025.
C1 Hunan University of Chinese Medicine, Zhu, Ruixin, Changsha, Hunan, China
   Changsha Hospital of Traditional Chinese Medicine, Li, Xing, Department of Acupuncture, Changsha, Hunan, China
   Changsha Hospital of Traditional Chinese Medicine, Yan, Zhaobo, Department of Acupuncture, Changsha, Hunan, China
   Changsha Hospital of Traditional Chinese Medicine, Chen, Cheng, Department of Acupuncture, Changsha, Hunan, China
   Changsha Hospital of Traditional Chinese Medicine, Zhai, Wei, Department of Acupuncture, Changsha, Hunan, China
   Changsha Hospital of Traditional Chinese Medicine, Zhang, Hengcai, Department of Acupuncture, Changsha, Hunan, China
   Changsha Hospital of Traditional Chinese Medicine, Ma, Wen Juan, Department of Acupuncture, Changsha, Hunan, China
   Changsha Hospital of Traditional Chinese Medicine, Wang, Fukun, Department of Acupuncture, Changsha, Hunan, China
   Hunan University of Chinese Medicine, Liu, Mi, School of Acupuncture, Changsha, Hunan, China
   Changsha Hospital of Traditional Chinese Medicine, Du, Geshu, Department of Acupuncture, Changsha, Hunan, China
CR Martel-Pelletier, Johanne P, 2016, Osteoarthritis @ Nature Reviews Disease Primers, V0, P2
   Woolf, Anthony D, 2003, Burden of major musculoskeletal conditions @ Bulletin of the World Health Organization, V81, P646-656
   Jiang, Yangzi, Osteoarthritis year in review 2021: biology, Osteoarthritis and Cartilage, 30, 2, pp. 207-215, (2022), 2022, Jiang @ Yangzi, VOsteoarthritis year in review 2021: biology, P207-215
   Glyn-Jones, Siôn, Osteoarthritis, The Lancet, 386, 9991, pp. 376-387, (2015), 2015, Glyn-Jones @ Siôn, VOsteoarthritis, P376-387
   Carr, Andrew Jonathan, Knee replacement, The Lancet, 379, 9823, pp. 1331-1340, (2012), 2012, Carr @ Andrew Jonathan, VKnee replacement, P1331-1340
   Pivec, Robert, Hip arthroplasty, The Lancet, 380, 9855, pp. 1768-1777, (2012), 2012, Pivec @ Robert, VHip arthroplasty, P1768-1777
   Bijlsma, Johannes W.J, 2011, Osteoarthritis: An update with relevance for clinical practice @ The Lancet, V377, P2115-2126
   Singh, Jasvinder A, 2023, Making the current non-surgical treatments for knee osteoarthritis more effective: Solutions from a diverse patient group @ Joint Bone Spine, V90, P3
   Tao, Tao, Evaluation of traditional Chinese exercise for knee osteoarthritis (KOA): an overview of systematic reviews, Systematic Reviews, 13, 1, (2024), 2024, Tao @ Tao, VEvaluation of traditional Chinese exercise for knee osteoarthritis (KOA): an overview of systematic reviews, P1
   Yang, Min, Traditional Chinese medicine for knee osteoarthritis: An overview of systematic review, PLOS ONE, 12, 12, (2017), 2017, Yang @ Min, VTraditional Chinese medicine for knee osteoarthritis: An overview of systematic review, P12
NR 10
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J9 SYST REV
JI Syst. Rev.
PD JUN 15
PY 2025
VL 14
IS 1
BP 
EP 
DI 10.1186/s13643-025-02762-x
PG 0
UT Scopus:10.1186/s13643-025-02762-x
ER

PT Article
AU Chen, Z
   Xu, T
   Yin, Z
   Li, Q
   Shu, Y
   Zhou, X
   Zhao, L
   Sun, M
   Liang, F
AF Chen, Ziwen
   Xu, Tao
   Yin, Zihan
   Li, Qifu
   Shu, Yunjie
   Zhou, Xueli
   Zhao, Ling
   Sun, Mingsheng
   Liang, Fanrong
TI Electroacupuncture for chemotherapy-induced gastrointestinal symptoms in colorectal cancer: protocol for a multicenter, three-arm, randomized controlled trial
SO International Journal of Colorectal Disease
LA English
DT Article
DE Chemotherapy; Colorectal cancer; Electroacupuncture; Gastrointestinal toxicity; Randomized controlled trial
ID adsorbent; corticosteroid; loperamide; serotonin 3 agonist; antineoplastic agent; abdominal distension; abdominal pain; acupuncturist; adult; aged; article; bile reflux; bleeding; blind evaluation scale; chemical ionization mass spectrometry; colorectal cancer; constipation; controlled study; cross validation; diarrhea; dizziness; ecog performance status; efficacy parameters; electroacupuncture; electrostimulation; female; follow up; functional assessment of cancer therapy colorectal scores; gastrointestinal symptom rating scale; gastrointestinal toxicity; hematoma; human; indigestion; infection; intention to treat analysis; internal consistency; intervention study; karnofsky performance status; linear mixed effects model; major clinical study; male; middle aged; multicenter study; nausea and vomiting; needle insertion; neiguan acupoint; outcome assessment; pain; pallor; protocol; quality control; quchi acupoint; randomized controlled trial; sample size; shangjuxu acupoint; standard care; sweating; zung self rating depression scale; zusanli acupoint; colorectal tumor; drug therapy; gastrointestinal disease; multicenter study (topic); quality of life; randomized controlled trial (topic); therapy; treatment outcome; adult; aged; antineoplastic agents; colorectal neoplasms; electroacupuncture; female; gastrointestinal diseases; humans; male; middle aged; multicenter studies as topic; quality of life; randomized controlled trials as topic; treatment outcome
AB Background: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality globally. While chemotherapy remains a cornerstone of CRC treatment, gastrointestinal (GI) toxicity—manifesting as abdominal pain, diarrhea, constipation, and reflux—affects 40%–100% of patients, severely impairing quality of life. Despite the prevalence of these symptoms, there is a lack of effective non-pharmacological interventions. This study aims to evaluate the efficacy of electroacupuncture (EA) in alleviating chemotherapy-induced GI dysfunction in CRC patients. Methods: In this multicenter, three-arm, randomized controlled trial (RCT), 231 CRC patients with post-chemotherapy GI symptoms will be centrally randomized to EA plus standard care, sham acupuncture (SA) plus standard care, or standard care alone. The EA and SA groups will receive three 30-min sessions over consecutive days, delivered by certified acupuncturists (EA: LI11, PC6, ST36 and ST37 with electrical stimulation; SA: non-acupoints with blunt-tip needles without stimulation). The primary outcome is the change in Gastrointestinal Symptom Rating Scale (GSRS) total scores from baseline to post-treatment (day 3). Secondary outcomes include GSRS subscale scores, Functional Assessment of Cancer Therapy-Colorectal (FACT-C) scores, and Self-Rating Anxiety Scale/Self-Rating Depression Scale (SAS/SDS) scores. All outcomes will be assessed at baseline (T0), post-intervention (T1: day 3), and follow-up (T2: day 10). Statistical analysis will employ intention-to-treat linear mixed-effects models. Conclusion: This multicenter RCT is designed to generate high-quality evidence on the comprehensive efficacy of EA in addressing chemotherapy-induced GI toxicity in CRC patients. If proven effective, EA could provide a safe, non-pharmacological adjunct to standard care, helping to reduce symptom burden and improve patient adherence to chemotherapy. Trial registration ChiCTR2200062317. Registered on 1 August 2022. © The Author(s) 2025.
C1 Chengdu University of Traditional Chinese Medicine, Chen, Ziwen, Acupuncture and Tuina School, Chengdu, Sichuan, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, Sichuan, China
   Sichuan Orthopedic Hospital, Xu, Tao, Department of Research, Chengdu, China
   Chengdu University of Traditional Chinese Medicine, Yin, Zihan, Acupuncture and Tuina School, Chengdu, Sichuan, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, Sichuan, China
   Chengdu University of Traditional Chinese Medicine, Li, Qifu, Acupuncture and Tuina School, Chengdu, Sichuan, China
   Chengdu University of Traditional Chinese Medicine, Shu, Yunjie, Acupuncture and Tuina School, Chengdu, Sichuan, China
   Chengdu University of Traditional Chinese Medicine, Zhou, Xueli, Acupuncture and Tuina School, Chengdu, Sichuan, China
   Chengdu University of Traditional Chinese Medicine, Zhao, Ling, Acupuncture and Tuina School, Chengdu, Sichuan, China
   Chengdu University of Traditional Chinese Medicine, Sun, Mingsheng, Acupuncture and Tuina School, Chengdu, Sichuan, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, Sichuan, China
   Chengdu University of Traditional Chinese Medicine, Liang, Fanrong, Acupuncture and Tuina School, Chengdu, Sichuan, China, Sichuan Provincial Acupuncture Clinical Medicine Research Center, Chengdu, Sichuan, China
CR Global Cancer Burden Growing Amidst Mounting Need for Services, (2024), 2024, Global Cancer Burden Growing Amidst Mounting Need for Services, V0, P0
   Eng, Cathy, A comprehensive framework for early-onset colorectal cancer research, The Lancet Oncology, 23, 3, pp. e116-e128, (2022), 2022, Eng @ Cathy, VA comprehensive framework for early-onset colorectal cancer research, Pe116-e128
   Patel, Swati G, 2024, Screening for Colorectal Cancer @ Annals of Internal Medicine, V177, PITC49-ITC64
   Baxter, Nancy Noel, Adjuvant Therapy for Stage II Colon Cancer: ASCO Guideline Update, Journal of Clinical Oncology, 40, 8, pp. 892-910, (2022), 2022, Baxter @ Nancy Noel, VAdjuvant Therapy for Stage II Colon Cancer: ASCO Guideline Update, P892-910
   Hu, Huabin, Neoadjuvant Chemotherapy With Oxaliplatin and Fluoropyrimidine Versus Upfront Surgery for Locally Advanced Colon Cancer: The Randomized, Phase III OPTICAL Trial, Journal of Clinical Oncology, 42, 25, pp. 2978-2988, (2024), 2024, Hu @ Huabin, VNeoadjuvant Chemotherapy With Oxaliplatin and Fluoropyrimidine Versus Upfront Surgery for Locally Advanced Colon Cancer: The Randomized, P2978-2988
   Patel, Swati G, 2022, The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology clinical features biology risk factors prevention and early detection @ The Lancet Gastroenterology and Hepatology, V7, P262-274
   Akbarali, Hamid I, 2022, Chemotherapy induced gastrointestinal toxicities @ Advances in Cancer Research, V155, P131-166
   Chen, Weiqian, Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer, Redox Biology, 10, pp. 78-89, (2016), 2016, Chen @ Weiqian, VSynergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer, P78-89
   Lee, Chunseng, Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: The role of inflammation, World Journal of Gastroenterology, 20, 14, pp. 3751-3761, (2014), 2014, Lee @ Chunseng, VGastro-intestinal toxicity of chemotherapeutics in colorectal cancer: The role of inflammation, P3751-3761
   Dahlgren, David, Chemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies, Frontiers in Pharmacology, 12, (2021), 2021, Dahlgren @ David, VChemotherapeutics-Induced Intestinal Mucositis: Pathophysiology and Potential Treatment Strategies, P12
NR 10
TC 0
SN 01791958
EI 
J9 INT J COLORECTAL DIS
JI Int. J. Colorectal Dis.
PD JUN 15
PY 2025
VL 40
IS 1
BP 
EP 
DI 10.1007/s00384-025-05008-3
PG 0
UT Scopus:10.1007/s00384-025-05008-3
ER

PT Article
AU Lukkahatai, N
   Benjasirisan, C
   Shen, A
   Li, J
   Allgood, SJ
   Thomas, F
   Karyukin, A
   Sheng, JY
   Engle, JP
   Lee, TY
   Saligan, LN
AF Lukkahatai, Nada
   Benjasirisan, Chitchanok
   Shen, Aomei
   Li, Junxin
   Allgood, Sarah j
   Thomas, Frank
   Karyukin, Artyom
   Sheng, Jennifer y
   Engle, Jessica p
   Lee, Ta ya
   Saligan, Leorey n
TI Combined technology-enhanced home exercise and acupressure (TEHEplus) program on symptoms among cancer patients receiving immunotherapy: a feasibility study
SO BMC Cancer
LA English
DT Article
DE Acupressure; Cancer; Exercise; Immunotherapy; Mobile health
ID nivolumab; pertuzumab; sipuleucel t; trastuzumab; acupressure; acupuncture point; adult; aged; anxiety; article; cancer patient; depression; exercise; fatigue; feasibility study; female; human; immunotherapy; male; pain; phase 1 clinical trial; phase 2 clinical trial; pilot study; randomization; short physical performance battery; sleep; social interaction; technology enhanced home exercise; very elderly; adverse event; clinical trial; controlled study; etiology; immunology; kinesiotherapy; middle aged; neoplasm; procedures; quality of life; randomized controlled trial; therapy; acupressure; aged; aged, 80 and over; exercise; exercise therapy; fatigue; feasibility study; female; humans; immunotherapy; male; middle aged; neoplasms; pilot projects; quality of life
AB Background: Cancer patients receiving immunotherapy often experience symptoms impacting their well-being. The present study aimed to develop and test the feasibility of a 12-week Technology-Enhanced Home Exercise and acupressure (TEHEplus) program to improve symptoms (fatigue, pain, sleep, anxiety, depression), social functioning, physical performance, and serum biomarkers (brain-derived neurotrophic factor, heat shock protein 90 levels.) Methods: A two-phase design was employed. Phase 1 involved program development; Phase 2 was a pilot feasibility study. Participants with solid tumor cancers were recruited from cancer centers in Maryland and randomly assigned to four groups: Usual Care Control (UC), Technology-Enhanced Home Exercise (TEHE) alone, Acupressure alone (ACU), and TEHEplus. Feasibility was measured by enrollment duration, intervention adherence, and daily survey response rates. Outcomes were measured at baseline and program completion. Results: In phase 1, four participants (age 56–82) provided feedback on online training, smartphone application, intervention duration, and outcome measures. In Phase 2, 40 participants (10 per group) were recruited over 12 months, with 43% (n = 17) completing all daily surveys. TEHEplus participants achieved 50% of exercise goals, and 78% adhered to the acupoint recommendations. TEHEplus participants showed significant improvements in fatigue (p = 0.02), pain inference (p = 0.30), and social functioning (p = 0.03); TEHE participants improved only in social functioning (p = 0.03). Conclusion: TEHEplus is feasible and shows promise for symptom alleviation. Preliminary findings suggest potential benefits in symptom management and functional outcomes. However, further studies with larger and more diverse samples are warranted to explore its efficacy and generalizability.Further studies with larger, more diverse populations are needed to confirm its efficacy. TEHEplus may enhance symptom management and improve functional outcomes for cancer survivors undergoing immunotherapy. Trial registration: ClinicalTrials.gov ID NCT03576274 Trial Registration Date: 06/07/2018. © The Author(s) 2025.
C1 Lukkahatai, Nada, Johns Hopkins School of Nursing, Baltimore, MD, United States
   Benjasirisan, Chitchanok, Johns Hopkins School of Nursing, Baltimore, MD, United States
   Tianjin Medical University Cancer Institute & Hospital, Shen, Aomei, Tianjin, Tianjin, China
   Li, Junxin, Johns Hopkins School of Nursing, Baltimore, MD, United States
   Johns Hopkins School of Nursing, Baltimore, MD, United States
   Thomas, Frank, Johns Hopkins School of Nursing, Baltimore, MD, United States
   Karyukin, Artyom, Johns Hopkins School of Nursing, Baltimore, MD, United States
   Johns Hopkins University School of Medicine, Baltimore, MD, United States
   Johns Hopkins University School of Medicine, Baltimore, MD, United States
   Johns Hopkins University School of Medicine, Lee, Ta Ya, Baltimore, MD, United States
   Rutgers School of Nursing, Newark, NJ, United States
CR Feng, Lina, Symptoms, symptom clusters and associated factors among cancer patients receiving immune checkpoint inhibitor therapy: A cross-sectional survey, European Journal of Oncology Nursing, 63, (2023), 2023, Feng @ Lina, VSymptoms, P63
   Yin, Qi'nan, Immune-related adverse events of immune checkpoint inhibitors: a review, Frontiers in Immunology, 14, (2023), 2023, Yin @ Qi'nan, VImmune-related adverse events of immune checkpoint inhibitors: a review, P14
   Wang, Yucai, Treatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis, JAMA Oncology, 5, 7, pp. 1008-1019, (2019), 2019, Wang @ Yucai, VTreatment-Related Adverse Events of PD-1 and PD-L1 Inhibitors in Clinical Trials: A Systematic Review and Meta-analysis, P1008-1019
   Petrelli, Fausto, Immune-related Adverse Events and Survival in Solid Tumors Treated with Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis, Journal of Immunotherapy, 43, 1, pp. 1-7, (2020), 2020, Petrelli @ Fausto, VImmune-related Adverse Events and Survival in Solid Tumors Treated with Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis, P1-7
   Yang, Xuying, Symptom clusters and symptom network analysis during immunotherapy in lung cancer patients, Supportive Care in Cancer, 32, 11, (2024), 2024, Yang @ Xuying, VSymptom clusters and symptom network analysis during immunotherapy in lung cancer patients, P11
   Guven, Deniz Can, The burden of polypharmacy and drug–drug interactions in older cancer patients treated with immunotherapy, Journal of Oncology Pharmacy Practice, 28, 4, pp. 785-793, (2022), 2022, Guven @ Deniz Can, VThe burden of polypharmacy and drug–drug interactions in older cancer patients treated with immunotherapy, P785-793
   Mao, Jun J, 2022, Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology-ASCO Guideline @ Journal of Clinical Oncology, V40, P3998-4024
   Mustian, Karen M, 2017, Comparison of pharmaceutical psychological and exercise treatments for cancer-related fatigue: A meta-analysis @ JAMA Oncology, V3, P961-968
   Hilfiker, Roger, Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment: A systematic review incorporating an indirect-comparisons meta-analysis, British Journal of Sports Medicine, 52, 10, pp. 651-658, (2018), 2018, Hilfiker @ Roger, VExercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment: A systematic review incorporating an indirect-comparisons meta-analysis, P651-658
   Smith, Lee, Cancer survivors’ attitudes towards and knowledge of physical activity, sources of information, and barriers and facilitators of engagement: A qualitative study, European Journal of Cancer Care, 26, 4, (2017), 2017, Smith @ Lee, VCancer survivors’ attitudes towards and knowledge of physical activity, P4
NR 10
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SN 14712407
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J9 BMC CANCER
JI BMC Cancer
PD JUN 15
PY 2025
VL 25
IS 1
BP 
EP 
DI 10.1186/s12885-025-14887-2
PG 0
UT Scopus:10.1186/s12885-025-14887-2
ER

PT Article
AU Wan, R
   Zheng, Q
   Zeng, X
   Luo, Y
   Sun, L
   Chen, S
   Luo, F
   Zhang, Y
   Zhu, Z
   Chen, X
   Zhao, Y
   Li, Y
AF Wan, Renhong
   Zheng, Qianhua
   Zeng, Xiaorui
   Luo, Yalan
   Sun, Luqiang
   Chen, Shuai
   Luo, Fangli
   Zhang, Yupeng
   Zhu, Ziyue
   Chen, Xinyun
   Zhao, Yuanyuan
   Li, Ying
TI Differential placebo effect of sham acupuncture for chronic pain: a network meta-analysis of randomized controlled trials
SO BMC Complementary Medicine and Therapies
LA English
DT Article
DE Chronic pain; Manual acupuncture; Meta-analysis; Placebo; Randomized controlled trial; Sham acupuncture
ID acupuncture; acupuncture point; article; chronic pain; chronic prostatitis; clinical practice; electroacupuncture; human; meta analysis; network meta-analysis; neuropathic pain; outcome assessment; pain intensity; pelvis pain syndrome; placebo effect; preferred reporting items for systematic reviews and meta-analyses; quality of life; randomized controlled trial (topic); sensitivity analysis; visceral pain; visual analog scale; network meta analysis (topic); procedures; therapy; placebo; acupuncture therapy; chronic pain; humans; network meta-analysis as topic; placebo effect; placebos; randomized controlled trials as topic
AB Background: The clinical effects of acupuncture are often underestimated due to the placebo effect of sham acupuncture. While multiple sham acupuncture methods have been used in clinical practice, it is challenging to select the appropriate sham acupuncture technique due to the lack of head-to-head trials. Purpose: The purpose of this study was to compare the differential placebo effects of diverse sham acupuncture interventions, providing evidence-based guidance for selecting optimal placebo controls in clinical practice. Method: PubMed, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science were systematically searched for randomized controlled trials comparing acupuncture with sham acupuncture for the treatment of chronic non-cancer pain (from inceptions to May 1, 2025). The primary outcome measure was pain variation, while secondary outcome measures included adverse events and the assessment of acupuncture blinding. Frequentist random-effect models were employed to perform indirect treatment comparison meta-analysis, and Confidence in Network Meta-Analysis (CINeMA) was utilized to evaluate the level of evidence. Results: A total of 45 randomized controlled trials (RCTs) were included, involving 7 sham acupuncture methods and 8287 participants. Regarding pain variation, the difference was noted between the waiting treatment group (mean difference 1.86 (95% confidence interval 1.36 to 2.35), SUCRA 97.4%; moderate confidence of evidence) and manual acupuncture group was most pronounced, followed by the difference between the acupoint and no penetration group (mean difference 1.14 (95% confidence interval 0.74 to 1.55), SUCRA 73.6%; low confidence of evidence) and the nonacupoint and no penetration group (mean difference 1.00 (95% confidence interval 0.35 to 1.65), SUCRA 64.8%; low confidence of evidence). Additionally, the rate of adverse events was comparable among the aforementioned sham acupuncture groups, and the blinding procedure was successfully implemented in the trials. Conclusions: The placebo effect of sham acupuncture is significant, among which the no penetration (acupoint or nonacupoint) groups exhibited the lowest placebo effect. Nevertheless, further head-to-head trials are warranted to obtain direct evidence. Systematic review registration: PROSPERO no. CRD42024535012. © The Author(s) 2025.
C1 Chengdu University of Traditional Chinese Medicine, Wan, Renhong, Acupuncture and Tuina School, Chengdu, Sichuan, China
   Chengdu University of Traditional Chinese Medicine, Zheng, Qianhua, Acupuncture and Tuina School, Chengdu, Sichuan, China
   Chengdu University of Traditional Chinese Medicine, Zeng, Xiaorui, Acupuncture and Tuina School, Chengdu, Sichuan, China
   Luzhou Longmatan TCM Hospital, Luo, Yalan, Luzhou, China
   Chengdu University of Traditional Chinese Medicine, Sun, Luqiang, Acupuncture and Tuina School, Chengdu, Sichuan, China
   Jiangxi University of Chinese Medicine, Chen, Shuai, Nanchang, Jiangxi, China
   Luo, Fangli, School of Integrated Traditional Chinese and Western Clinical Medicine, North Sichuan Medical College, Nanchang, Sichuan, China
   Chengdu University of Traditional Chinese Medicine, Zhang, Yupeng, Acupuncture and Tuina School, Chengdu, Sichuan, China
   Chengdu University of Traditional Chinese Medicine, Zhu, Ziyue, Acupuncture and Tuina School, Chengdu, Sichuan, China
   Chengdu University of Traditional Chinese Medicine, Chen, Xinyun, Acupuncture and Tuina School, Chengdu, Sichuan, China
   Chengdu University of Traditional Chinese Medicine, Zhao, Yuanyuan, Acupuncture and Tuina School, Chengdu, Sichuan, China
   Chengdu University of Traditional Chinese Medicine, Li, Ying, Acupuncture and Tuina School, Chengdu, Sichuan, China
CR Beecher, Henry K, 1955, The powerful placebo @ JAMA, V159, P1602-1606
   Kaptchuk, Ted J, 2000, Do medical devices have enhanced placebo effects? @ Journal of Clinical Epidemiology, V53, P786-792
   Zhang, Yuqing, How to design high quality acupuncture trials - A consensus informed by evidence, BMJ, (2024), 2024, Zhang @ Yuqing, VHow to design high quality acupuncture trials - A consensus informed by evidence, PBMJ
   Streitberger, Konrad M, 1998, Introducing a placebo needle into acupuncture research @ The Lancet, V352, P364-365
   Park, Jongbae J, 2002, Validating a new non-penetrating sham acupuncture device: Two randomised controlled trials @ Acupuncture in Medicine, V20, P168-174
   Takakura, Nobuari, A double-blind placebo needle for acupuncture research, BMC Complementary and Alternative Medicine, 7, (2007), 2007, Takakura @ Nobuari, VA double-blind placebo needle for acupuncture research, P7
   Wang, Yuting, Analysis of placebo effect of acupuncture, Zhen Ci Yan Jiu, 49, 8, pp. 875-879, (2024), 2024, Wang @ Yuting, VAnalysis of placebo effect of acupuncture, P875-879
   Zheng, Hui, Acupuncture for Patients With Chronic Tension-Type Headache: A Randomized Controlled Trial, Neurology, 99, 14, pp. E1560-E1569, (2022), 2022, Zheng @ Hui, VAcupuncture for Patients With Chronic Tension-Type Headache: A Randomized Controlled Trial, PE1560-E1569
   Zeng, Dian, Placebo response varies between different types of sham acupuncture: A randomized double-blind trial in neck pain patients, European Journal of Pain, 26, 5, pp. 1006-1020, (2022), 2022, Zeng @ Dian, VPlacebo response varies between different types of sham acupuncture: A randomized double-blind trial in neck pain patients, P1006-1020
   Lee, Ye-seul, ACURATE: A guide for reporting sham controls in trials using acupuncture, Journal of Evidence-Based Medicine, 16, 1, pp. 82-90, (2023), 2023, Lee @ Ye-seul, VACURATE: A guide for reporting sham controls in trials using acupuncture, P82-90
NR 10
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J9 BMC COMPL MEDTHERAPIES
JI BMC Compl. Med.Therapies
PD JUN 15
PY 2025
VL 25
IS 1
BP 
EP 
DI 10.1186/s12906-025-05055-x
PG 0
UT Scopus:10.1186/s12906-025-05055-x
ER

